4Ĭoronaviruses can cause multiple systemic infections or injuries in various animals. As of March 5, 2020, there were 95 333 confirmed cases of COVID- deaths globally. 3 Therefore, this virus was named SARS-CoV-2, and in February 2020, the World Health Organization (WHO) named the disease coronavirus disease 2019 (COVID-19). 2 Both shared the same receptor, angiotensin-converting enzyme 2 (ACE2). 1 The novel CoV was reported to have symptoms resembling that of severe acute respiratory syndrome CoV (SARS-CoV) in 2003.

This outbreak was confirmed to be caused by a novel coronavirus (CoV). In December 2019, many unexplained pneumonia cases occurred in Wuhan, China, and rapidly spread to other parts of China, then to Europe, North America, and Asia. Role of the Funder/Sponsor: The funding sourceshad no role in the design and conduct of the study collection, management, analysis, and interpretation of the data preparation, review, or approval of the manuscript and decision to submit the manuscript for publication. Hu, No.81974182 to Dr Mao and 81671147 to Dr Jin) and Major Refractory Diseases Pilot Project of Clinical Collaboration with Chinese and Western Medicine (SATCM-20180339). Hu), the National Natural Science Foundation of China (81820108010 to Dr B. Hu.Ĭonflict of Interest Disclosures: None reported.įunding/Support: This work was supported by the National Key Research and Development Program of China (2018YFC1312200 to Dr B. Hu.Īdministrative, technical, or material support: Mao, Jin, M. Hu.Ĭritical revision of the manuscript for important intellectual content: Y. Wang, Li.ĭrafting of the manuscript: Mao, Jin, M.

Hu.Īcquisition, analysis, or interpretation of data: Mao, Jin, M. Hu, Chen, He, and Chang contributed equally and share first authorship.Ĭoncept and design: Mao, Jin, Y. Hu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Corresponding Authors: Bo Hu, MD, PhD ( and Yanan Li, MD, PhD ( Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Īccepted for Publication: March 26, 2020.

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